Difference between side effect and adverse effect of drugs
Usually side effect is define as an unintended secondary effect which occurs alone with the desired therapeutic effect of a drug or medication.it can be vary form one person another person it may depend on the individual persons disease state, age, weight, gender, general health factors.
WHO define side effect as ‘Unintended effect occurring at normal dose related to the pharmacological properties
Side effects occurs with an usher of decreasing/increasing dosages, or terminating a drug or medication regimen. Side effects may also lead to non-compliance with prescribed treatment. When side effects of a drug or medication are severe, the dosage may be adjusted or a second medication may be prescribed. Lifestyle or dietary changes may also help to minimize side effects.
side effect and adverse drug reactions are conditions which are generally experienced by the health care providers often they are interchanged or used instead of the other, but wrongly so.
Example of the side effect includes the patient might not be aware of the side effect of diarrhea while using antibiotics but the physician is very well aware about it. Doctors generally advise patients not to pay attention to side effects unless severe and often warn their patients regarding their possibility. Side effects are published by pharmaceutical companies as soon as a new drug is launched in the market owing to the extensive clinical trials that are conducted before launching it in the market for general use.
An adverse effect is an ‘undesired effect and very harmful effect. Adverse drug effects are experienced by patient’s may be due to lack of physician’s knowledge about the complete or perfect action of the drug and hence, can be called as iatrogenic in nature. The adverse effects can often lead to deterioration of the health condition for which the drug was originally initiated and worsen the prognosis of the disease. So adverse effects can deteriorate the treatment, lead to a complication or combine with the pre-existing disease and form a totally new disorder which is difficult to treat. One must be careful while using the term side effect as it refers to a reaction which is known but not expected by the physician whereas if one uses the term adverse effect then it implies that the reaction was a totally unexpected one and needs immediate medical attention to correct it.
list of major drugs with side effect.
1.Ampicillin- Hypersensitivity
2. Amphotericin.B- Nephrotoxicity
3. Androgen- Virilization
4. Antipsychotics- Sedation, Orthostatic hypotension, Tardive dyskinesia
5. Anti- TB- Hepatotoxicity
6. Aspirin (cox-I Inhibitors)- Hepatotoxicity
7. ACE Inhibitors- Dry Cough
8. Atropine – Dryness of mouth, Blurred vision, Constipation
9. Chlorambucil- Alopecia
10.Celecoxib,Valdecoxib (cox-II Inhibitors)-cardio and Hepatotoxicity
11.Chloroquine – Phototoxicity
12.Chloramphenicol- Grey baby syndrome, Bone marrow depression
13. Ciprofloxacin – Phototoxicity
14. Clofazimine- Pigmentation of skin, Discoloration of Urine
15. Clozapine – Agranulocytosis
16. Erythromyicin- Cholestatic Juandice
17. Ethambutol – Optic Neuritis, Retrobulbular Neuritis
18. Hydrochlorthiazide- Hypokalamia
19. Isoniazid – Peripheral Neurtis
20. Metronidazole- Disulfiram like reaction
21. Minoxidil- Hirsutism
22. Morphine- Constipation
23. Nimesulide – Hepatotoxicity
24. Nitrogen Mustard- Bone marrow depression
25. Nitroglycerin- Palpitation
26. Penicillin. G- Jarisch Heximer Reaction
27. Phenformin- Lactic acidosis, GI disturbance, Metalic taste
28. Phenytoin- Hirsutism
29. Quinidine- Cinchonism
30. Quinine Sulphate- Black Water Fever
31. Repaglinide- Althralgia
32. Rosaglitazone- Anemia,Weight gain
33. Sitagliptin- Coldness
34. Spironolactone- Hyperkalamia
35. Cimetidine- Gynacomastia
37. Sulfonyl Ureas derivatives- Bone marrow depression
38. Terfenadine- Type-I arrhythmia
39. Tetracyclines- Discoloration of teeth
40. Thalidomide- Phocomelia
