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Home›Medical research›Will Appendix Be Key for Parkinson’s Disease?

Will Appendix Be Key for Parkinson’s Disease?

By Ramoju kishore kumar
November 4, 2018
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A new research has suggest that removing of the appendix could lower the risk for Parkinson’s disease. In that research work conducted by the Swedish residents, they follows and analysis that how appendix removal surgery (appendectomy) affected Parkinson’s risk among 1.6 million. Finally they couldn’t prove cause and effect, but it found that appendectomy patient has the lowered risk of Parkinson’s disease roughly 20 percent.

Inorder to investigate researches has searched the data from Swedish National Patient Registry. SNPR is unique because since 1964 it has maintained a full record of diagnoses and surgeries of the Swedish patient pool,  of the 1.6 million covered patients, more than 550,000 had undergone an appendectomy.

Resident Viviane Labrie from Van Andel Research Institute in Grand Rapids has said that “This is a tissue that most people consider to be a useless organ. It’s attached to the large intestine, and it’s removed as a very common surgical practice,”

Dr. Norman Sharpless details why doctors develop clinical trials, potential benefits, and how they bring new therapies to the rest of the world.The new findings suggest, “that the appendix may be a tissue site that plays a role in the initiation of Parkinson’s disease,” she said.

Why? “The hallmark pathology of Parkinson’s disease in the brain is Lewy bodies, which is characterized by a clumped form of a protein called alpha-synuclein,” Labrie explained.What’s more, clumps of this protein are found in the intestinal tract and are “present in the appendixes of all of us,” sometimes years before Parkinson’s symptoms arise, she said.

So, “we think that if in rare events [such protein clumps] were to escape the appendix and enter the brain, this could lead to Parkinson’s disease.” How? Simply by traveling up the nerve that connects the intestinal tract directly to the brain, Labrie said.

As we all know that Parkinsonism is a neurodegenrative condition. Common among the complications of Parkinson’s is the onset of gastrointestinal dysfunction — including constipation — which can actually precede mobility loss by as much as 20 years. This signaled a potential link between Parkinson’s onset and the appendix, the researchers explained.

After following Parkinson’s incidence for up to 52 years post-surgery, investigators found that Parkinson’s was ultimately diagnosed in 1.2 out of every 1,000 appendectomy patients, compared to a risk of 1.4 out of every 1,000 people in the general Swedish population.That meant that Parkinson’s risk had dropped by 19.3 percent among those who had had their appendix removed.What’s more, after honing in on the specific experiences of about 850 Parkinson’s patients, the researchers determined that appendix removal was also associated with a 3.6-year delay in the onset of Parkinson’s among those who had the surgery and still developed the disease.

Still, Labrie stressed that “we are not saying that having an appendix causes Parkinson’s disease, and that all people should go out and remove their appendix.”

Rather, “we think that what actually distinguishes a person that goes on to develop Parkinson’s from one that does not is not the presence of this pathology, but rather the factors that trigger departure from the appendix.” That raises the prospect for developing new therapies designed to prevent such protein clumps from escaping the appendix.

The findings were published in the Oct. 31 issue of Science Translational Medicine.

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